Diterpenoid Irritants and Cocarcinogens in Euphorbiaceae and Thymelaeaceae: Structural Relationships in View of their Biogenesis
- 1 January 1977
- journal article
- research article
- Published by Wiley in Israel Journal of Chemistry
- Vol. 16 (1) , 75-83
- https://doi.org/10.1002/ijch.197700015
Abstract
Diterpene esters exhibiting toxic, irritant, cocarcinogenic as well as antileukemic activities have been isolated from many Euphorbiaceae and Thymelaeaceae species. They contain the structurally closely related polycyclic skeletons of tigliane, daphnane and ingenane. They are being used in all facets of cancer research as both tumor promoters and inhibitors. They are also considered as second‐order carcinogenic risk factors in the etiology of human cancer. The authors review possible biosynthetic pathways for the plant diterpenes and discuss structural relationships in view of their biogenesis.Keywords
This publication has 64 references indexed in Scilit:
- Tumor inhibitors. 111. Structure and stereochemistry of jatrophone, a novel macrocyclic diterpenoid tumor inhibitorJournal of the American Chemical Society, 1976
- Synthesis of casbeneJournal of the Chemical Society, Chemical Communications, 1976
- Resiniferatoxin and other esters of novel polyfunctional diterpenes from euphorbia resinifera and unispinaTetrahedron Letters, 1975
- On the irritant and cocarcinogenic principles of hippomane mancinellaTetrahedron Letters, 1975
- New diterpene esters from Aleurites fordii fruitsPhytochemistry, 1975
- Toxic substances of EuphorbiaceaePure and Applied Chemistry, 1975
- Diterpene esters from ‘Euphorbium’ and their irritant and cocarcinogenic activityCellular and Molecular Life Sciences, 1974
- Neocembrene-A, a termite trail pheromoneJournal of the Chemical Society, Perkin Transactions 1, 1972
- The crystal and molecular structure of cembreneActa Crystallographica Section B: Structural Science, Crystal Engineering and Materials, 1969
- Cembrene, A 14-Membered Ring Diterpene HydrocarbonJournal of the American Chemical Society, 1962