A Controlled Family Study of Live, Attenuated Rubella-Virus Vaccine

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Abstract
In a family study of live, attenuated rubella-virus vaccine (HPV80), 85 susceptible placebo recipients were exposed to siblings with evidence of infection with the vaccine strain of rubella virus after inoculation. Of these placebo recipients a rise in titer of hemagglutination-inhibiting antibody developed in one. The type of antibody response and her clinical course indicated that vaccine virus infection had occurred. Although this response might have resulted from her having received vaccine by mistake, the possibility of intrafamilial spread of vaccine-strain virus must be seriously considered.

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