ON RAT SERUM LIPASE II. THE EFFECT OF VARIOUS EXPERIMENTAL STATES

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Abstract
Further studies are presented on the enzyme in rat serum which hydrolyzes tripropionin, tributyrin, and ethyl butyrate. There is an increase from low levels at birth to normal adult serum lipase activity by about the fourth week of life. The concentration of the enzyme remains quite constant from day to day providing the animals are not bled too frequently, i.e. not more often than once a day. Starvation for a week does not alter serum lipase activity. Additional studies confirm the earlier finding that the lipolytic activity of rat serum ia elevated by alloxan diabetes, and it is shown that insulin, administered over a 24 hr. period, produces a partial return toward normal activity of the enzyme. Decreased serum lipase levels resulted from castration of male and female rats, injection of diethylstilboestrol into normal and gonadectomized animals of both sexes, and late pregnancy. These decreases were all significant, although some of them were transient. It appears that some profound hormonal disturbances may be responsible for these changes.
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