A Computer Generated Model of Adenosine Receptors Rationalising Binding and Selectivity of Receptor Ligands
- 1 July 1991
- journal article
- oral communications
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 10 (5) , 1121-1124
- https://doi.org/10.1080/07328319108047251
Abstract
Computer graphic analyses on a broad spectrum of adenosine receptor ligands has shown that both the A1 and A2 adenosine receptors have three binding sites. The spatial relationship of these three binding sites has been defined. Adenosine orientation at A1 and A2 is different.Keywords
This publication has 3 references indexed in Scilit:
- C2,N6-Disubstituted adenosines: synthesis and structure-activity relationshipsJournal of Medicinal Chemistry, 1989
- N6-[2-(3,5-dimethoxyphenyl)-2-(2-methylphenyl)ethyl]adenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity for the adenosine A2 receptorJournal of Medicinal Chemistry, 1988
- N6-Substituted N-alkyladenosine-5'-uronamides: bifunctional ligands having recognition groups for A1 and A2 adenosine receptorsJournal of Medicinal Chemistry, 1986