Vitamins C and B12-Reply

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Abstract
In Reply.— We were interested to learn that in none of the ten patients of Afroz et al with spinal cord injury did low serum vitamin B12levels develop after more than 11 months of therapy with 4 gm of ascorbic acid daily. However, the fact that three of their ten patients had serum vitamin B12 levels above the upper limit of the normal range suggests either that their vitamin B12assay procedure is giving erroneously high results or, more likely, they are dealing with a group of patients with a high frequency of liver disease, in which situation the serum vitamin B12level is abnormally elevated despite tissue depletion of. vitamin B12. It would be useful to know whether their patients present hematologic evidence of vitamin B12deficiency, such as macroovalocytes and hypersegmented neutrophils in the peripheral blood, anemia, leukopenia, or granulopenia, as well

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