Propranolol and the Ventilatory Response to Hypoxia and Hypercapnia in Normal Man

1 November 1978

journal article
research article
Published by Portland Press Ltd. in Clinical Science

Vol. 55 (5) , 491-497
https://doi.org/10.1042/cs0550491

Abstract

1. The effect on respiration of a single dose of propranolol has been studied in normal subjects. 2. The degree of β-adrenoreceptor blockade was assessed in terms of the impaired heart-rate response to progressive exercise and the plasma propranolol concentration. 3. No effect of propranolol was demonstrated on either the ventilatory response to rebreathing CO₂ in hyperoxia, or the response to progressive isocapnic hypoxia. Simple indices of maximal expiratory flow (FEV_1.0% and PEFR) were also unchanged. 4. The absence of any effect of propranolol on the chemical control of breathing in man is discussed in relation to the conflicting literature.

Keywords

This publication has 1 reference indexed in Scilit:

THE EFFECT OF NORADRENALINE INFUSION ON THE RELATION BETWEEN PULMONARY VENTILATION AND THE ALVEOLAR Po₂ AND Pco₂, IN MAN
Annals of the New York Academy of Sciences, 1963