ENTERITIS OF EARLY WEANED PIGS .2. PATHOGENESIS

  • 1 January 1964
    • journal article
    • research article
    • Vol. 28  (11) , 272-+
Abstract
When cell-free extracts prepared from a frequently isolated Escherichia coli[long dash]0139K82(B) were injected 48 hours apart into a healthy pig, symptoms of edema disease were produced. Similar symptoms were produced when this extract was injected into a colostrum-deprived pig raised in isolation. The Schultz-Dale reaction revealed no difference between the contractions of the ilea of sensitized and non-sensitized guinea pigs. In vitro treatment of a single non-sensitized guinea pig uterus with extracts of 5 different strains of hemolytic E. coli produced sharp contractions. A similar treatment with extracts of 4 non-hemolytic E. coli strains also stimulated the non-sensitized guinea pig uterus but the magnitude of the contractions was much less. These studies indicated that the cell-free extracts of hemolytic E. coli produced a marked nonspecific toxic reaction.