Reduction of 3,5-disubstituted pyridines to dihydropyridines
- 1 January 1975
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Perkin Transactions 1
- No. 10,p. 929-931
- https://doi.org/10.1039/p19750000929
Abstract
The reduction of pyridine-3,5-dicarboxylates by sodium borohydride to give the corresponding 1,2- and 1,4-dihydropyridines has been investigated, and the compositions of the isomer mixtures produced in various solvents have been determined. New syntheses have been developed for 3,5-disubstituted 1,4-dihydropyridines involving reduction with sodium cyanoborohydride, and for 1,2-dihydropyridine-3,5-dicarboxylates involving reduction with diborane. Details of the previously reported catalytic hydrogenation of pyridines are given.Keywords
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