TOTAL FREE TOCOPHEROLS IN THE SERUM OF PATIENTS WITH THYROID DISEASE 1

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Abstract
The concentration of tocopherol in the serum of 29 patients with untreated Graves'' disease was 0.74+0.20 mg% compared with values of 1.21+0.23 mg% for 53 individuals in the euthyroid state and 2.29+0.38 mg% in 18 hypothyroid patients. Tocopherol concentrations showed significant negative correlation with BMR, serum protein-bound iodine concentration and 24-hour uptake of radioactive iodine. Concentrations of tocopherol were lowest among patients with severe Graves'' disease, but emaciation as such was not a critical variable. Abnormalities in serum tocopherol concentrations in thyro-toxic and hypothyroid patients generally paralleled alterations in cholesterol level and were uniformly reversed upon restoration of normal metabolic state.