Antibodies to brain proteins in paraneoplastic cerebellar degeneration
- 1 September 1986
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 36 (9) , 1169
- https://doi.org/10.1212/wnl.36.9.1169
Abstract
A 68-year-old man had subacute cerebellar degeneration and a non-Hodgkin's lymphoma. Using an immunoblotting method, we found serum antibodies to rat cerebral 250-kd and 110-kd and cerebellar 110-kd acidic cytoplasmic proteins. The antibodies did not react unless the antigens were prepared soon after death with protease inhibitors. Two hundred fifty-kd and 110-kd proteins are minor components of soluble cytoplasmic proteins of the brain. The molecular weights differed from other soluble brain-specific proteins already characterized.This publication has 7 references indexed in Scilit:
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