Functional capacity of sex‐reversed (XX, Sxr/ +) mouse germ cells as shown by progeny derived from XX, Sxr/ + oocytes of a female chimera

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Abstract
Mice of the genotype X/X, Sxr/ + (Sex‐reversed) are sterile phenotypic males. Testis size is reduced and there is a failure of spermatoge‐nesis during meiosis I. A female chimeric mouse has been produced whose germ line is entirely composed of X/X, Sxr/ + germ cells. The progeny of this chimera included several XX, Sxr/ + males. The finding that X/X, Sxr/ + germ cells can produce fully functional oocytes has implications for the function of the Sex‐reversed gene, the control of germ cell differentiation, and the role of germ cells in primary sex determination.

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