Lack of Association Between Depression and Loss of Neurons in the Locus Coeruleus in Alzheimer Disease

Open Access

1 January 1999

journal article
research article
Published by American Medical Association (AMA) in Archives of General Psychiatry

Vol. 56 (1) , 45-51
https://doi.org/10.1001/archpsyc.56.1.45

Abstract

ALZHEIMER DISEASE (AD) is generally considered a disturbance of cognition. Recently, however, depressive and other psychiatric symptoms have gained more interest, since these symptoms may seriously increase caregiver burden and are frequently the reason for hospitalization.¹ This is also of practical clinical relevance since depressive symptoms in patients with AD can be successfully treated with selective serotonin reuptake inhibitors.² These cause little postural hypotension³ and can be used relatively safely in the elderly and for AD, whereas no effective treatment is, at present, available for AD itself.

Keywords

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