GUILLAIN-BARRÉ SYNDROME AN ALLERGIC REACTION?
- 7 March 1966
- journal article
- research article
- Published by American Medical Association (AMA)
- Vol. 195 (10) , 862
- https://doi.org/10.1001/jama.1966.03100100114038
Abstract
Despite Guillain's statement (1953) of belief in a viral origin and rejection of an allergic basis for the Guillain-Barré syndrome, many investigators now regard this syndrome as an allergic reaction of the nervous system. Attempts to establish an infectious etiology continue, but none are conclusive. Perhaps pathologic evidence first suggested a hypersensitivity reaction; edema of the nerve roots in the first four days is followed by disintegration of myelin, swelling of axons, and finally lymphocytic infiltration. This early and marked swelling of the radicals, so apparent at the dural aperture that it is called the Denny-Brown tourniquet effect, is frequently considered an allergic response. The conviction that the syndrome results from an allergic reaction of the nervous system is restated in a recent issue of theArchives of Neurology.1Evidence which began with experimental allergic encephalomyelitis fostered the conclusions. Waksman and Adams in 1955, using an admixture of rabbitKeywords
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