New antiarrhythmic agents. N-Aryl-8-pyrrolizidinealkanamides

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Abstract
The synthesis and antiarrhythmic activity of N-aryl-8-pyrrolizidinealkanamides are described. The target compounds were evaluted for their ability to protect against chloroform-induced fibrillation in mice. Many of them had antifibrillatory activity comparable to that of lidocaine; several are more potent than lidocaine. N-(2,6-Dimethylphenyl)-8-pyrrolizidineacetamide, which was more potent and less toxic (LD50) than lidocaine, showed a long duration of action in dogs with ventricular arrhythmias after oral administration.

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