Segmental necrosis in tenotomized muscle fibers

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Abstract
A study of the soleus muscle of the rat along its entire length during the first week following tenotomy was undertaken. Within the first few days the affected fibers of the soleus underwent a complete morphological reorganization. Portions of fibers near the tendons were Invaded by and replaced with a large population of phagocytes. Previous studies have implied that the number of sarcomeres in series is reduced, but it has not been demonstrated from what portion of the fiber the sarcomeres are revoved. Sections of fibers taken from the mid‐belly region demonstrated a progressive degenerative process over the first few days. Myofibrils across the entire width of the affected fibers underwent dissolution and degeneration. Fibers with central core lesions could be found by the seventh day after tenotomy, however, at this stage the peripheral myofibrils were new, and the fibers had begun the regenerative process which continued until normal fiber histology was restored.