Penetration into inflammatory exudate and wounds of two cephalosporins for the prevention of surgical infections

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Abstract
The skin abrasion technique has been used to measure the inflammatory exudate levels of cefa.zolin and cephaloridine in patients undergoing elective surgery. These levels were compared with serum and wound concentrations. Inflammatory exudate concentrations of both antibiotics were almost identical to serum concentrations and considerably higher than the measured wound concentrations. For cephaloridine, peak concentrations in serum and exudate were reached synchronously. For cefazolin the transfer from serum to inflammatory exudate was significantly delayed. Therefore, the skin abrasion technique, in conjunction with serum concentrations gives additional information about antibiotic transport in man. In inflammatory exudate, serum and wounds, cefazolin achieved higher concentrations than did the same dose of cephaloridine.

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