Gene for glutathione S-transferase-1 (GST1) is on human chromosome 11
- 1 September 1982
- journal article
- research article
- Published by Springer Nature in Somatic Cell and Molecular Genetics
- Vol. 8 (5) , 667-675
- https://doi.org/10.1007/bf01542859
Abstract
The glutathione S-transferases (GST) are a group of related enzymes that can detoxify potentially carcinogenic electrophiles by conjugating them with reduced glutathione (GSH). The chromosomal location of one of the enzyme forms, GST1,reported recently to be polymorphic, was determined utilizing man-mouse somatic cell hybrids segregating human chromosomes. The expression of GST1by hybrid clones was compared with that of 34 enzyme markers representing 23 chromosomes, and karyotypes of selected cell hybrids were analyzed. The evidence indicated that GST1is assigned to chromosome 11 in humans. Utilizing an X/11 translocation segregating in hybrids, GST1was localized to the p13→ qter region of chromosome 11.This publication has 27 references indexed in Scilit:
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