Cerebral Cortical Metabolism After Chronic Exposure to Ozone

Publisher Website
Google Scholar
Abstract
This study represents a biochemical survey of cerebral cortex in dogs, in which an increased latency of evoked electroencephalogram EEG potentials of visual cortex had been observed after prolonged exposure to ozone. Portions of occipital and parietal cortex were analyzed from 44 dogs which had been exposed to 1 to 3 ppm O3 for 18 months. Contents of norepinephrine and epinephrine, lipid hydroperoxides, K+, Na+, and Cl- were measured. In addition, the activity of the following enzymes was determined: monoamine oxidase, catechol-O-methyltransferase, cholînesterase, 5’-nu-cleotidase, and Na+, K+, and Mg++ adenosine triphosphatases (ATP’ases). Catechol-O-methyltransferase activity showed a steady decline as the daily exposure to 1 ppm O3 was increased from 8 to 24 hours. Concurrently, the catecholamine content of the tissues declined.

This publication has 16 references indexed in Scilit: