OSTEOBLASTS AND OSTEOCLASTS IN BONE MARROW ASPIRATION

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Abstract
SIR JAMES PAGET'S classic report1on osteitis deformans was followed by numerous investigations2which have established the protean clinical manifestations, the specific pathological picture, the biochemical alteration, and the roentgenographic abnormalities which characterize this condition whose causation still remains obscure. Although the clinical diagnosis is often made readily, at times there may be great difficulty in differentiating Paget's disease from other bone disorders, especially from osteoblastic cancer metastases.3 In this communication, hitherto undescribed cell findings in bone marrow aspirates will be reported. These cell findings were noted in eight consecutive cases of Paget's disease and consist of large mononuclear cells and giant multinucleated syncytial forms, both of which have unique morphological characteristics. The detailed cytology of these cells and their significance will be presented below. INITIAL OBSERVATIONS Early in 1952, an iliac bone marrow smear from a patient (Case 1) with suspected pernicious anemia was examined by

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