Distinct lineages of TH1 cells have differential capacities for memory cell generation in vivo
- 12 August 2002
- journal article
- research article
- Published by Springer Nature in Nature Immunology
- Vol. 3 (9) , 852-858
- https://doi.org/10.1038/ni832
Abstract
We studied here the long-term maintenance of distinct populations of T helper type 1 (TH1)-lineage cells in vivo and found that effector TH1 cells, defined by their secretion of interferon-γ (IFN-γ), are short-lived and do not efficiently develop into long-term memory TH1 cells. In contrast, a population of activated TH1-lineage cells that did not secrete IFN-γ after primary antigenic stimulation persisted for several months in vivo and developed the capacity to secrete IFN-γ upon subsequent stimulation. These data suggest that a linear differentiation pathway, as defined by the transition from IFN-γ–producing to resting memory cells, is relatively limited in vivo and support a revised model for TH1 memory differentiation.Keywords
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