Significance of anti-inflammatory effects of PPAR agonists?
- 27 September 2005
- Vol. 55 (8) , 1067-1069
- https://doi.org/10.1136/gut.2005.089946
Abstract
The peroxisome proliferator activated receptor γ (PPARγ) is one of three members of the PPAR family (PPARα and PPARδ), which itself is a part of the nuclear hormone receptor superfamily.1–5 Nuclear hormone receptors are transcription factors that are activated by the binding of small lipophilic ligands.6,7,8,9,10,11 They induce or repress transcription of a large number of different genes thereby influencing cellular functions.Keywords
This publication has 54 references indexed in Scilit:
- Peroxisome proliferator activated receptor in colonic epithelial cells protects against experimental inflammatory bowel diseaseGut, 2005
- Intestinal antiinflammatory effect of 5-aminosalicylic acid is dependent on peroxisome proliferator–activated receptor-γThe Journal of Experimental Medicine, 2005
- A novel PPARγ gene therapy to control inflammation associated with inflammatory bowel disease in a murine modelGastroenterology, 2003
- Peroxisome proliferator‐activated receptor‐γ (PPAR‐γ) activation suppresses ischemic induction of Egr‐1 and its inflammatory gene targetsThe FASEB Journal, 2002
- Natural ligands of PPARγ:: Are prostaglandin J2 derivatives really playing the part?Cellular Signalling, 2002
- Suppression of Gastric Mucosal Inflammatory Responses to Helicobacter pylori Lipopolysaccharide by Peroxisome Proliferator‐Activated Receptor γ ActivationIUBMB Life, 2002
- Metabolic and Additional Vascular Effects of ThiazolidinedionesDrugs, 2002
- Troglitazone, a Ligand for Peroxisome Proliferator‐activated Receptor γ Inhibits Chemically‐induced Aberrant Crypt Foci in RatsJapanese Journal of Cancer Research, 2001
- A gut check for PPARγGastroenterology, 1998
- Inhibition of Adipogenesis Through MAP Kinase-Mediated Phosphorylation of PPARγScience, 1996