Scopoletin: An Inducible Nitric Oxide Synthesis Inhibitory Active Constituent from Artemisia feddei
- 1 June 1999
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 65 (5) , 400-403
- https://doi.org/10.1055/s-1999-14014
Abstract
Bioassay-guided fractionation of an H2O extract of Artemisia feddei has furnished an inducible nitric oxide synthase (iNOS) inhibitory coumarin, scopoletin (1) and one of the inactive sesquiterpenes, achillin (2). Compound 1 showed inhibition of nitric oxide (NO) synthesis in a dose-dependent manner in murine macrophage-like RAW 264.7 cells stimulated with interferon-γ (IFN-γ) plus lipopolysaccharide (LPS). The Inhibition of NO synthesis of 1 was due to suppression of iNOS mRNA and iNOS protein, as determined by Northern and Western blotting, respectively.Keywords
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