Regulation of the two "malic" enzymes in Neurospora crassa

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Abstract
Two NADP-specific "malic" enzymes have been found to be present in Neurospora crassa. They have different pH optima and are influenced differently by some metabolites and inhibitors. The pH 8.0 "malic" enzyme appears during the early stages of growth and is inhibited by fructose 1,6-diphosphate while the pH 10.0 "malic" enzyme appears during the later stages of growth and is inhibited by aspartate. Both enzymes are repressed by acetate and pyruvate and their activities are inhibited by glyoxylate and oxaloacetate. The metabolic function of the enzymes is discussed.

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