Immunotherapy of Cancer With Nonliving Mycobacteria and Cord Factor (Trehalose-6,6′-dimycolate) in Aqueous Medium

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Abstract
Heat-killed BCG, cord factor (trehalose-6,6′-dimycolate), or killed BCG plus cord factor in aqueous medium, ad-mixed with tumor cells and injected into the skin of guinea pigs, inhibited the growth of a hepatocellular carcinoma. Intralesional administration of killed BCG or Mycobacterium kansasii coated with cord factor, in the same medium, caused regression of established tumors in 48 and 45% of the treated animals, respectively.