Factors influencing the mutagenic activity of the colon carcinogen 1,2-dimethylhydrazine in Salmonella typhimurium strain TA 1535 in vitro
- 1 January 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 5 (4) , 467-472
- https://doi.org/10.1093/carcin/5.4.467
Abstract
Transformation of mouse C3H 10T1/2 cells by various alkylating carcinogens can be modulated by inhibiting poly-(ADP-ribose) synthesis with a low concentration of 3-aminobenzamide, which induces no additional toxicity or reported side effects. Transformation by methylating agents was decreased by 3-aminobenzamide, whereas transformation by ethylating agents was increased. These results confirm earlier work on transformation by methylating agents, X-rays and u.v. light. Transformation by ethylating agents, however, appears to proceed by a different mechanism.This publication has 15 references indexed in Scilit:
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