Immunoglobulins in Urine from Patients with Ileal and Colonic Conduits and Reservoirs

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Abstract
Gel chromatography of proteins in urine from continent cecal urinary reservoirs revealed an abundance of high MW proteins, especially secretory IgA. Quantitation of Ig in urine from ileal and colonic conduits and ileal and cecal reservoirs showed secretory IgA, G and M in amounts considerably greater than in urine from normal urinary tracts, whether or not bacteriuria was present. More secretory IgA was found in reservoir than in conduit urine, but there was no such difference for IgG and IgM. In hemagglutination-inhibition tests, IgA antibodies from ceca reservoir urine in 1 patient inhibited adherence (mannose-resistant) to human and animal erythrocytes of Escherichia coli obtained from reservoir urine from that same patient. High levels of secretory IgA may constitute a host defense mechanism against urinary tract infection in patients with reservoirs and conduits.