Resistance to Macrolide, Lincosamide, Streptogramin, Ketolide, and Oxazolidinone Antibiotics
- 1 January 2004
- journal article
- review article
- Published by Springer Nature in Molecular Biotechnology
- Vol. 28 (1) , 47-62
- https://doi.org/10.1385/mb:28:1:47
Abstract
Macrolides have enjoyed a resurgence as new derivatives and related compounds have come to market. These newer compounds have become important in the treatment of community-acquired pneumoniae and nontuberculosis-Mycobacterium diseases. In this review, the bacterial mechanisms of resistance to the macrolide, lincosamide, streptogramin, ketolide, and oxazolidinone antibiotics, the distribution of the various acquired genes that confer resistance, as well as mutations that have been identified in clinical and laboratory strains are examined.Keywords
This publication has 95 references indexed in Scilit:
- Isolation of Tetracycline-Resistant Megasphaera elsdenii Strains with Novel Mosaic Gene Combinations of tet (O) and tet (W) from SwineApplied and Environmental Microbiology, 2003
- Linezolid in vitro: mechanism and antibacterial spectrumJournal of Antimicrobial Chemotherapy, 2003
- Staphylococcus sciuri Gene erm (33), Encoding Inducible Resistance to Macrolides, Lincosamides, and Streptogramin B Antibiotics, Is a Product of Recombination between erm (C) and erm (A)Antimicrobial Agents and Chemotherapy, 2002
- Detection of Oxazolidinone-Resistant Enterococcus faecalis and Enterococcus faecium Strains by Real-Time PCR and PCR-Restriction Fragment Length Polymorphism AnalysisJournal of Clinical Microbiology, 2002
- 23S rRNA point mutation associated with erythromycin resistance inTreponema denticolaFEMS Microbiology Letters, 2002
- Binding Site of Macrolide Antibiotics on the Ribosome: New Resistance Mutation Identifies a Specific Interaction of Ketolides with rRNAJournal of Bacteriology, 2001
- Horizontal Gene Transfer in Prokaryotes: Quantification and ClassificationAnnual Review of Microbiology, 2001
- Cloning and nucleotide sequence of themphBgene for macrolide 2′-phosphotransferase II inEscherichia coliFEMS Microbiology Letters, 1996
- Missense mutations that alter the DNA-binding domain of the MtrR protein occur frequently in rectal isolates of Neisseria gonorrhoeae that are resistant to faecal lipidsMicrobiology, 1995
- Streptomyces antibioticus contains at least three oleandomycin‐resistance determinants, one of which shows similarity with proteins of the ABC‐transporter superfamilyMolecular Microbiology, 1993