Hybridization with human cells corrects the elevated SCE frequency and BrdU hypersensitivity of hamster cell line EM9
- 31 December 1984
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 39 (2) , 154-157
- https://doi.org/10.1159/000132126
Abstract
Cells of the Chinese hamster line EM9 exhibit an elevated SCE frequency and a decreased proliferative response in bromodeoxyuridine (BrdU)-containing medium. Here, these phenotypic features were examined experimentally using polyethylene glycol fusion of EM9 and normal human cells. EM9/human hybrids exhibited both normal SCE frequencies and normal proliferative responses in BrdU-containing medium, suggesting that SCE elevation and BrdU hypersensitivity in EM9 have a common molecular basis.Keywords
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