Relative Role of Milk Agent and Tissue Sensitivity in Estrogen Induced Mammary Growth

Abstract
The mamary glands of ovariectomized mice of strains Z, D2 and A possessing the milk agent were more susceptible to estrogenic stimulation than the breasts of mice of the same strains raised for many generations without the milk agent. However, strain differences in the mamary response to the estrogen continued to exist also in the absence of the milk agent. These variations are considered to be due to strain differences in the susceptibility of the target tissue to hormonal stimulation.