A Rapid, Sensitive Method for Quantifying Enflurane in Whole Blood

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Abstract
Thermal conductivity detection (TCD) in conjunction with GLC was employed for the analysis of enflurane, a halogenated anesthetic, in n-heptane extracts of whole human blood. Enflurane was estimated to be 98% extracted from whole blood by n-heptane. Analysis of enflurane standards ranging in concentration from 4.1-813 .mu.M demonstrated linearity, with a correlation coefficient of 0.9999. As little as 8 .mu.M enflurane may be detected in whole blood. TCD GLC is a rapid and sensitive method for quantifying enflurane in whole blood.

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