Effect of Hyperbaric Oxygen and Surgery on Experimental Gas Gangrene
- 1 January 1992
- journal article
- research article
- Published by S. Karger AG in European Surgical Research
- Vol. 24 (6) , 356-362
- https://doi.org/10.1159/000129228
Abstract
An experimental model of clostridial gas gangrene was developed in rats and the therapeutic value of surgical debridement alone versus a combination of surgery and hyperbaric oxygen (HBO) was assessed. The infection was produced by an intramuscular injection of Clostridium perfringens microorganisms. The mortality of untreated rats was 100%. The mortality of the rats treated only with surgery was 37.5% compared to 12.5% when HBO was added to the treatment protocol (pKeywords
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