Maternal and paternal origin of extra chromosome in trisomy 21

1 January 1976

journal article
research article
Published by Springer Nature in Human Genetics

Vol. 32 (1) , 17-21
https://doi.org/10.1007/bf00569972

Abstract

Fluorescence markers were studied in 40 patients with Down's syndrome and their parents. In 11 cases maternal and in 5 cases paternal non-disjunction could be shown. The disjunctional event occurred in the first meiotic division in 5 maternal and in 2 paternal cases. A second division failure was found in 4 maternal and 2 paternal cases. In 3 cases the failure could either be of first or second meiotic division origin.

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