Neuroleptics differentially induce jun family genes in the rat striatum
- 12 January 1994
- journal article
- molecular neuroscience
- Published by Wolters Kluwer Health in NeuroReport
- Vol. 5 (4) , 501-503
- https://doi.org/10.1097/00001756-199401120-00033
Abstract
The effect of neuroleptics in single administration on the expression of genes of the jun family was studied in the rat striatum. jun B, but not jun D was dose-dependently and transiently induced. This effect was blocked by pretreatment with a specific dopamine D2 agonist. The expression of c-jun was also stimulated, although this did not reach statistical significance. Thus dopamine D2 receptors differentially regulate the expression of jun family members in the striatum.Keywords
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