HYPERINSULINAEMIA IN HYPERPROLACTINAEMIC WOMEN

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Abstract
The metabolic sequelae of hyperprolactinemia were studied over 12 h of normal meals and activity in 9 young female hyperprolactinemic subjects and 14 matched controls. In the patients, fasting blood glucose and serum insulin concentrations were normal, as was the blood glucose response to meals; the insulin rise with meals was exaggerated and hyperinsulinemia persisted throughout the day (mean .+-. standard error of the mean 12 h serum insulin, 26 .+-. 8 vs. 16 .+-. 9 mu/l, P < 0.01). Blood lactate, pyruvate and alanine response to meals was also increased. Blood glycerol (mean 12 h blood glycerol 0.06 .+-. 0.01 vs. 0.09 .+-. 0.01 mmol/l, P < 0.01) and blood 3-hydroxybutyrate (mean 12 h blood 3-hydroxybutyrate 0.03 .+-. 0.01 vs. 0.05 .+-. 0.01 mmol/l, P < 0.05) concentrations were lower in hyperprolactinemic subjects. There was a strong negative correlation between mean insulin and mean 3-hydroxybutyrate levels in the afternoon period (r = -0.92, P < 0.01). Excess circulaitng prolactin in young females is associated with normoglycemic hyperinsulinemia. The changes in blood metabolite levels observed are probably secondary to the increased insulin concentrations.