Lowered platelet glutathione peroxidase activity in patients with intrinsic asthma
- 1 October 1990
- Vol. 45 (7) , 523-527
- https://doi.org/10.1111/j.1398-9995.1990.tb00528.x
Abstract
Platelet glutathione peroxidase (GSH-Px) activity and serum selenium (Se) levels were determined in 20 patients with intrinsic asthma. Nine of the patients had NSAID-intolerance. The mean value of GSH-Px activity in the patients was 47.0±7.1 U/1011 platelets, which is significantly lower than that of 56.4±12 U/1011 platelets in the controls (P < 0.01). There was also a tendency towards lowered Se levels in the patients compared with controls. The results are discussed in view of the protective role of GSH-Px against oxidative stress and the tentative regulatory function of GSH-Px in arachidonic acid metabolism.Keywords
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