Bullous Eruption with Circulating Pemphigus-Like Antibodies following Interferon-Alpha Therapy
- 1 January 1993
- journal article
- case report
- Published by S. Karger AG in Dermatology
- Vol. 186 (2) , 155-157
- https://doi.org/10.1159/000247329
Abstract
Two patients with classic Kaposi sarcoma developed bullous lesions and pemphigus-like ‘anti-intercellular-substance’ antibodies when treated with interferon-α (IFN-α). In one of them direct immunofluorescence was consistent with pemphigus/pemphigoid features. The immunoprecipitation test showed no specific bands. The mechanism by which IFN-α may induce the production of anti-intercellular-substance antibodies is discussed.Keywords
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