Congenital chromosome breakage clusters within Giemsa-light bands and identifies sites of chromatin instability
- 1 January 1988
- journal article
- research article
- Published by S. Karger AG in Cytogenetic and Genome Research
- Vol. 49 (4) , 269-274
- https://doi.org/10.1159/000132675
Abstract
Analysis of the distribution of published chromosome breaks in cells with constitutional chromosome aberrations showed a nonrandom distribution of breaks among chromosomes and chromosome regions. A significant amount of breakage occurred at Giemsa-negative bands. In addition, chromosome sites associated with a number of fragile sites and cellular oncogeneKeywords
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