PRIMATE MESENTERIC BLOOD-FLOW - EFFECTS OF VASOPRESSIN AND ITS ROUTE OF DELIVERY

  • 1 January 1978
    • journal article
    • research article
    • Vol. 74  (5) , 875-878
Abstract
The effects of vasopressin on blood flow in the superior mesenteric artery and on mean arterial pressure and portal venous pressure were measured in 7 rhesus monkeys. Vasopressin was injected, as either a bolus, or infused both intravenously and intraarterially to assess the influence of the route of administration upon hemodynamic responses. Dose-dependent decreases in superior mesenteric arterial flow were observed during both intraarterial and i.v. injections of vasopressin. No statistically significant differences between the 2 routes of administration, the decreases in flow and changes in pressure were observed. Based upon these observations, one might anticipate that i.v. administered vasopressin will be as effective as intraarterially administered vasopressin in reducing mesenteric blood flow, and thus portal venous pressure, in man.