Involvement of cyclic AMP-dependent protein kinases in the signal transduction pathway for interleukin-1.
Open Access
- 1 July 1990
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 10 (7) , 3824-3827
- https://doi.org/10.1128/mcb.10.7.3824
Abstract
Expression of a highly specific protein inhibitor for cyclic AMP-dependent protein kinases in interleukin-1 (IL-1)-responsive cells blocked IL-1-induced gene transcription that was driven by the kappa immunoglobulin enhancer or the human immunodeficiency virus long terminal repeat. This inhibitor did not affect protein kinase C-mediated gene transcription, suggesting that cyclic AMP-dependent protein kinases are involved in the signal transduction pathway for IL-1 in a number of responsive cell types.This publication has 23 references indexed in Scilit:
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