Serum Protein Binding of Phenytoin and Valproic Acid in Insulin-Dependent Diabetes Mellitus
- 1 December 1987
- journal article
- research article
- Published by Wolters Kluwer Health in Therapeutic Drug Monitoring
- Vol. 9 (4) , 389-391
- https://doi.org/10.1097/00007691-198712000-00005
Abstract
The serum protein binding of valproic acid (VPA) and phenytoin (PHT) was determined in spiked serum samples collected from 17 patients with insulin-dependent diabetes mellitus and 16 healthy control subjects. The free fraction of VPA was significantly greater in patients than in controls (7.6 .+-. 1.6% vs. 6.2 .+-. 1.2%, p < 0.01); for PHT, free fraction values were similar in the two groups (8.2 .+-. 1.1% vs. 8.4 .+-. 1.2%). The free fraction of VPA in diabetic patients was positively correlated with free fatty acid (FFA) concentration (r = 0.79, p < 0.01). No significant relationships could be found between free drug fraction and either serum albumin or glycosylated protein concentration.This publication has 5 references indexed in Scilit:
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