A NEW SYNTHETIC COMPOUND WITH ANTITUBERCULOUS ACTIVITY IN MICE - ETHAMBUTOL (DEXTRO-2,2'-(ETHYLENEDIIMINO)-DI-1-BUTANOL)

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Abstract
Dextro-2,2''-(ethylenediimino)-di-l-butanol has activity in vivo and in vitro against mycobacteria. It is active orally as well as parenterally, and it is active against strains of Mycobacterium tuberculosis which are resistant to isoniazid and streptomycin. On an oral dosage basis, the efficacy (tolerance/potency) index of the new compound is similar to that of isoniazid; parenterally it is superior to streptomycin. The new drug is compatible in combinations with isoniazid, as well as with streptomycin.

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