Recurrent aphthous ulceration. Effect of sera and peripheral blood lymphocytes upon oral epithelial tissue culture cells.

  • 1 November 1969
    • journal article
    • Vol. 17  (5) , 709-14
Abstract
In order to elucidate the possible role of humoral and cellular immune mechanisms in the pathogenesis of recurrent aphthous ulceration, a series of tissue culture experiments was undertaken in which oral epithelial cells were used as target cells. The survival of the oral epithelial cells was assessed, after culture for 24 hours, with the addition of sera, lymphocytes, or both sera and lymphocytes, from patients with recurrent aphthous ulceration and from persons free of the disease. In the experiments in which serum alone was added, there was no significant difference between the patients with recurrent aphthous ulceration and the controls.