Chlorosilane-Mediated 1,2-Addition of Organocuprates to α,β-Unsaturated Aldehydes: A Case of Vinylogous Cram's Rule
- 1 January 1992
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1992 (04) , 309-310
- https://doi.org/10.1055/s-1992-21350
Abstract
In the presence of trialkylchlorosilane, addition of a cuprate reagent to α,β-unsaturated γ-alkoxy aldehydes 1 takes place in a 1,2-addition mode with good diastereoselectivity, providing a case of vinylogous Cram's rule.Keywords
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