Synthesis and hypotensive activity of benzopyran derivatives.

Publisher Website
Google Scholar
Abstract
A series of dihydrobenzopyranyloxypropanolamines and dihydrobenzopyranylethanolamines containing a nitroxy moiety was synthesized. The cardiovascular effects of these compounds were investigated in anesthetized dogs. Some of the compounds exhibited hypotensive activity in combination with .beta.-adrenergic blocking and vasodilating action. The structure-activity relationships are discussed.