Comparative in Vitro Activity of Norfloxacin and Seven Other Antimicrobial Agents against Clinical Isolates from Urinary Tract Infections

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Abstract
The in vitro activity of norfloxacin, a new quinolone derivative, was tested against 469 clinical isolates derived mainly from urinary samples from outpatients. It inhibited all Escherichia coli, Klebsiella oxytoca and Proteus strains at a concentration of 0.25 μg/ml, and all Pseudomonas aeruginosa, Enterobacter, Klebsiella pneumoniae, Staphylococcus and Enterococcus strains at a concentration of 8 μg/ml or less. Norfloxacin proved to be more effective than nalidixic acid, trimethoprim, mecillinam and nitrofurantoin against all gram-negative rods tested.

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