EFFECT OF PROPOFOL, THIOPENTONE AND ETOMIDATE ON ADRENAL STEROIDOGENESIS IN VITRO
- 1 May 1985
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 57 (5) , 505-508
- https://doi.org/10.1093/bja/57.5.505
Abstract
The i.v. anesthetic agents propofol, thiopentone and etomidate inhibited ACTH-stimulated production of cortisol by guinea pig dispersed adrenal cells in a dose-related manner. For 2 of the drugs, propofol and thiopentone, inhibition occurred over a similar concentration range: 2 .times. 10-5 - 5 .times. 10-4 mol/l. With etomidate, inhibition occurred over a much lower concentration range (5 .times. 10-8 - 5 .times. 10-6 mol/l). The concentrations of anesthetic which induced 50% inhibition of cortisol secretion were propofol 1.7 .times. 10-4 thiopentone 1.6 .times. 10-4 and etomidate 1.0 .times. 10-7 mol/l.This publication has 5 references indexed in Scilit:
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