Male Germline Stem Cells: From Mice to Men
Top Cited Papers
- 20 April 2007
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 316 (5823) , 404-405
- https://doi.org/10.1126/science.1137741
Abstract
The production of functional male gametes is dependent on the continuous activity of germline stem cells. The availability of a transplantation assay system to unequivocally identify male germline stem cells has allowed their in vitro culture, cryopreservation, and genetic modification. Moreover, the system has enabled the identification of conditions and factors involved in stem cell self-renewal, the foundation of spermatogenesis, and the production of spermatozoa. The increased knowledge about these cells is also of great potential practical value, for example, for the possible cryopreservation of stem cells from boys undergoing treatment for cancer to safeguard their germ line.Keywords
This publication has 20 references indexed in Scilit:
- piRNAs in the Germ LineScience, 2007
- Self renewal, expansion, and transfection of rat spermatogonial stem cells in cultureProceedings of the National Academy of Sciences, 2005
- Conservation of spermatogonial stem cell self-renewal signaling between mouse and ratProceedings of the National Academy of Sciences, 2005
- ERM is required for transcriptional control of the spermatogonial stem cell nicheNature, 2005
- Expression patterns of cell-surface molecules on male germ line stem cells during postnatal mouse developmentMolecular Reproduction and Development, 2005
- Maintenance of spermatogenesis requires TAF4b, a gonad-specific subunit of TFIIDGenes & Development, 2005
- Culture Conditions and Single Growth Factors Affect Fate Determination of Mouse Spermatogonial Stem Cells1Biology of Reproduction, 2004
- Long-Term Proliferation in Culture and Germline Transmission of Mouse Male Germline Stem Cells1Biology of Reproduction, 2003
- Regulation of Cell Fate Decision of Undifferentiated Spermatogonia by GDNFScience, 2000
- Culture of mouse spermatogonial stem cellsTissue and Cell, 1998