Disoxaril Stabilization and Immunogenicity of Poliovirus Procapsids

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Abstract
Disoxaril (5-[7-[4-(4,5-dihydro-2-oxazolyl)phenoxy]-heptyl]-3-methylisoxazole) protects poliovirus procapsides against alkaline dissociation and thermal denaturation up to 42.degree. C. When added during the purification of procapsids, it enhances their yield and antigenic quality. Disoxaril increases the immunogenicity of both purified virions and procapsids in mice. Whereas untreated procapsids mainly elicit H-specific antibodies, disoxaril-treated procapsids yield high titres of neutralizing antibodies. The prospect of using disoxarial-treated procapsids in vaccines is discussed.

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