DNA replication in eukaryotes: a model for the specific involvement of chromatin subunits
- 1 January 1976
- journal article
- review article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 3 (1) , 69-78
- https://doi.org/10.1093/nar/3.1.69
Abstract
A model is proposed whereby eukaryotic DNA replication is specifically directed by the 200 base pair repeat structure of the DNA-histone complex. The model proposes a mechanism for the sequential, bidirectional replication of DNA from initial origin points on the chromatin fibre and is consistent with the known properties of eukaryotic DNA replication. Several predictions can be made from the model which are amenable to testing.Keywords
This publication has 27 references indexed in Scilit:
- The subunit structure of sea urchin sperm chromatin: A kinetic approachFEBS Letters, 1975
- Characterization of purified DNA-relaxing enzyme from human tissue culture cells.Proceedings of the National Academy of Sciences, 1975
- Comparison of the digestion of nuclei and chromatin by staphylococcal nucleaseBiochemistry, 1975
- Effects of cycloheximide on chromatin biosynthesisJournal of Molecular Biology, 1975
- Assembly of DNA and protein during replication in HeLa cellsNature, 1975
- Covalent linkage between RNA and nascent DNA in the slime mold, Physarum polycephalumBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1975
- Quaternary structure of chromatin.Proceedings of the National Academy of Sciences, 1975
- The subunit structure of the eukaryotic chromosomeNature, 1975
- Discontinuous DNA Replication in Mouse P‐815 CellsEuropean Journal of Biochemistry, 1975
- The reaction of the Ca-Mg endoauclease with the A-sites of rat nucleoproteinNucleic Acids Research, 1975