Comparison of Metabolic Effect of Ammonia and Adrenaline Infusions in Sheep
- 22 January 1979
- journal article
- research article
- Published by Wiley in Quarterly Journal of Experimental Physiology and Cognate Medical Sciences
- Vol. 64 (1) , 23-29
- https://doi.org/10.1113/expphysiol.1979.sp002455
Abstract
I.v. infusions of NH4Cl (62.3 .mu.mol kg-1 min-1) for 30 min caused a significant increase in blood glucose, lactate, pyruvate and free fatty acid (FFA) levels. A similar effect was also observed during adrenaline[epinephrine] infusion. Propranolol, a .beta.-receptor blocking agent, completely prevented the rise of blood pyruvate and lactate after adrenaline when 8.3 .mu.g kg-1 min-1 of propranolol were infused, but not after NH4Cl administration. Lipolytic actions of adrenaline were completely prevented but that of NH4Cl was only significantly diminished by blockade of .beta.-receptors with propranolol. The influence of NH4+ ions on blood lactate and pyruvate and FFA was not entirely mediated by adrenaline.This publication has 3 references indexed in Scilit:
- The Influence of Increasing Amounts of NH4CI in the Diet on Ammonia Detoxication in RatsZentralblatt für Veterinärmedizin Reihe A, 2010
- Effect of Hyperammonaemia on Blood Glucose and Plasma Insulin Levels in SheepQuarterly Journal of Experimental Physiology and Cognate Medical Sciences, 1979
- The colorimetric micro-determination of long-chain fatty acidsBiochemical Journal, 1963